SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis

SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis

Familial amyotrophic lateral sclerosis (ALS) is an incurable, late-onset motor neuron disease, linked strongly to various causative genetic loci. ALS8 codes for a missense mutation, P56S, in VAMP-associated protein B (VAPB) that causes the protein to misfold and form cellular aggregates. Uncovering...

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Bibliographic Details
Main Authors: Kriti Chaplot, Lokesh Pimpale, Balaji Ramalingam, Senthilkumar Deivasigamani, Siddhesh S. Kamat, Girish S. Ratnaparkhi
Format: Article
Language:English
Published: The Company of Biologists 2019-02-01
Series:Disease Models & Mechanisms
Subjects:
ALS
Autophagy
UPS
Aggregate
Rapamycin
MG132
Online Access:http://dmm.biologists.org/content/12/2/dmm033803

Internet

http://dmm.biologists.org/content/12/2/dmm033803

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