Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C

Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C

In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+ T cells toward a peculiar differentiation state known as T cell exhaustion, which poses crucial constraints to antiviral immunity. Available evidence indicates that T cell exhaustion is associated with a se...

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Bibliographic Details
Main Authors: Valeria Barili, Andrea Vecchi, Marzia Rossi, Ilaria Montali, Camilla Tiezzi, Amalia Penna, Diletta Laccabue, Gabriele Missale, Paola Fisicaro, Carolina Boni
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
chronic hepatitis
T cell exhaustion
immune-modulation
HBV
HCV
Online Access:https://www.mdpi.com/2073-4409/10/10/2563

Internet

https://www.mdpi.com/2073-4409/10/10/2563

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