The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis

The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis

Trigeminal neuralgia (TN) is a severe chronic neuropathic pain. Despite numerous available medical interventions, the therapeutic effects are not ideal. To control the pain attacks, the need for more contemporary drugs continues to be a real challenge. Our previous study reported that Ca2+-activated...

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Bibliographic Details
Main Authors: Zhan-ying Lu, Juan Fan, Li-hua Yu, Bei Ma, Li-ming Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
trigeminal neuralgia
TNF-α
trigeminal nucleus caudalis
MAPKs phosphorylation
BKCa channel
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.764141/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.764141/full

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