Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies

Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies

The amyloid-β (Aβ) peptide and tau protein are thought to play key neuropathogenic roles in Alzheimer’s disease (AD). Both Aβ and tau self-assemble to form the two major pathological hallmarks of AD: amyloid plaques and neurofibrillary tangles, respectively. In t...

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Bibliographic Details
Main Authors: Qiuchen Zheng, Micheal T. Kebede, Merc M. Kemeh, Saadman Islam, Bethany Lee, Stuart D. Bleck, Liliana A. Wurfl, Noel D. Lazo
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
Alzheimer′s disease
amyloid-β self-assembly
tau self-assembly
tau hyperphosphorylation
amyloid assemblies
neurofibrillary tangles
polyphenols
Online Access:https://www.mdpi.com/1420-3049/24/12/2316

Internet

https://www.mdpi.com/1420-3049/24/12/2316

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