Gromwell ameliorates glucocorticoid-induced muscle atrophy through the regulation of Akt/mTOR pathway

Gromwell ameliorates glucocorticoid-induced muscle atrophy through the regulation of Akt/mTOR pathway

Abstract Background Muscle atrophy is characterized by decreased muscle mass, function, and strength. Synthetic glucocorticoids, including dexamethasone (Dexa), are commonly used to treat autoimmune diseases. However, prolonged exposure of Dexa with high dose exerts severe side effects, including mu...

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Bibliographic Details
Main Authors: Ahyoung Yoo, Jung-In Kim, Hyunjung Lee, Farida S. Nirmala, Jeong-Hoon Hahm, Hyo Deok Seo, Chang Hwa Jung, Tae Youl Ha, Jiyun Ahn
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Chinese Medicine
Subjects:
Gromwell
Lithospermum erythrorhizon
Dexamethasone
Muscle atrophy
Lithospermic acid
mTOR/glucocorticoid receptor
Online Access:https://doi.org/10.1186/s13020-024-00890-5

Internet

https://doi.org/10.1186/s13020-024-00890-5

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