The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to chronic inflammation. The NLRP3 inflammasome...

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Bibliographic Details
Main Authors: Farraj Albalawi, Wennan Lu, Jonathan M. Beckel, Jason C. Lim, Stuart A. McCaughey, Claire H. Mitchell
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
IL-1β
astrocytes
glaucoma
pannexin
ATP release
NFκB
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00227/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00227/full

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