Inhibition of Acetylcholinesterase and Amyloid-β Aggregation by Piceatannol and Analogs: Assessing In Vitro and In Vivo Impact on a Murine Model of Scopolamine-Induced Memory Impairment

Inhibition of Acetylcholinesterase and Amyloid-β Aggregation by Piceatannol and Analogs: Assessing In Vitro and In Vivo Impact on a Murine Model of Scopolamine-Induced Memory Impairment

Currently, no drug is effective in delaying the cognitive impairment of Alzheimer’s disease, which ranks as one of the top 10 causes of death worldwide. Hydroxylated stilbenes are active compounds that exist in fruit and herbal plants. Piceatannol (PIC) and gnetol (GNT), which have one extra hydroxy...

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Bibliographic Details
Main Authors: Yi-Yan Sie, Liang-Chieh Chen, Cai-Jhen Li, Yu-Hsiang Yuan, Sheng-Hung Hsiao, Mei-Hsien Lee, Ching-Chiung Wang, Wen-Chi Hou
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Antioxidants
Subjects:
acetylcholinesterase
amyloid-β peptide
hydroxylated stilbenes
neurite outgrowth
passive avoidance test
piceatannol (PIC)
Online Access:https://www.mdpi.com/2076-3921/12/7/1362

Internet

https://www.mdpi.com/2076-3921/12/7/1362

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