Discovery and characterization of naturally occurring chalcones as potent inhibitors of bile salt hydrolases

Discovery and characterization of naturally occurring chalcones as potent inhibitors of bile salt hydrolases

Bile salt hydrolases (BSHs) play crucial roles in the deconjugation of conjugated bile acids and therefore are key targets for modulating bile acid metabolism. This study aimed to identify efficacious BSH inhibitors from a natural compound library and to characterize their inhibitory mechanisms. The...

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Bibliographic Details
Main Authors:	Chun-Yu Li, Hao-Nan Wang, Guang-Hao Zhu, Li-Lin Song, Xu-Dong Hou, Peng-Chao Huo, Jie Hou, Guang-Bo Ge
Format:	Article
Language:	English
Published:	Compuscript Ltd 2022-05-01
Series:	Acta Materia Medica
Subjects:	bile salt hydrolases (bshs) inhibitor licochalcone c isobavachalcone inhibitory mechanism
Online Access:	https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0003

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