Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits
Prevention of relapses is a major challenge in treating anxiety disorders. Fear reinstatement can cause relapse in spite of successful fear reduction through extinction-based exposure therapy. By utilising a contextual fear-conditioning task in mice, we found that reinstatement was accompanied by de...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/08274 |