Fast Dissolving Sublingual Films Containing Sumatriptan Alone and Combined with Methoclopramide: Evaluation in Vitro Drug Release and Mucosal Permeation

Fast Dissolving Sublingual Films Containing Sumatriptan Alone and Combined with Methoclopramide: Evaluation in Vitro Drug Release and Mucosal Permeation

ackground: Sumatriptan succinate is a 5-HT1 receptor agonist which is used in the treatment of migraine. It shows low bioavailability (15%) due to high hepatic first pass metabolism. The present work intended to formulate mucoadhesive sublingual films of sumatriptan combined with metoclopramide and...

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Bibliographic Details
Main Author: Maryam Maghsoodi, Mahdieh Rahmani, Hamed Ghavimi, Seyed Hassan Montazam, Saieede Soltani, Mitra Alami, Sara Salatin, Mitra Jelvehgari
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2016-10-01
Series:Pharmaceutical Sciences
Subjects:
Sumatriptan succinate
Metoclopramide
Mucoadhesive
Hydroxypropyl methylcellulose
Film
Online Access:http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_823_20151221110114

Internet

http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_823_20151221110114

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