Cortical thinning over two years after first-episode psychosis depends on age of onset
Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-03-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-021-00196-7 |
| _version_ | 1797642835582779392 |
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| author | Laura Pina-Camacho Kenia Martinez Covadonga M. Diaz-Caneja Gisela Mezquida Manuel J. Cuesta Carmen Moreno Silvia Amoretti Ana González-Pinto Celso Arango Eduard Vieta Josefina Castro-Fornieles Antonio Lobo David Fraguas Miguel Bernardo Joost Janssen Mara Parellada PEPs Group |
| author_facet | Laura Pina-Camacho Kenia Martinez Covadonga M. Diaz-Caneja Gisela Mezquida Manuel J. Cuesta Carmen Moreno Silvia Amoretti Ana González-Pinto Celso Arango Eduard Vieta Josefina Castro-Fornieles Antonio Lobo David Fraguas Miguel Bernardo Joost Janssen Mara Parellada PEPs Group |
| author_sort | Laura Pina-Camacho |
| collection | DOAJ |
| description | Abstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe. |
| first_indexed | 2024-03-11T14:06:02Z |
| format | Article |
| id | doaj.art-3dea36f302c74c848414a7113dc1a41c |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-11T14:06:02Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-3dea36f302c74c848414a7113dc1a41c2023-11-02T02:00:53ZengNature Portfolionpj Schizophrenia2334-265X2022-03-01811910.1038/s41537-021-00196-7Cortical thinning over two years after first-episode psychosis depends on age of onsetLaura Pina-Camacho0Kenia Martinez1Covadonga M. Diaz-Caneja2Gisela Mezquida3Manuel J. Cuesta4Carmen Moreno5Silvia Amoretti6Ana González-Pinto7Celso Arango8Eduard Vieta9Josefina Castro-Fornieles10Antonio Lobo11David Fraguas12Miguel Bernardo13Joost Janssen14Mara Parellada15PEPs GroupDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad ComplutenseDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad ComplutenseDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad ComplutenseBarcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute; Department of Medicine, Institut de Neurociències, Universitat de Barcelona; CIBERSAM; August Pi I Sunyer Biomedical Research Institute (IDIBAPS)Psychiatry Department, Complejo Hospitalario de Navarra, Pamplona, Spain Navarra Institute for Health Research (IdiSNA)Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad ComplutenseBarcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute; Department of Medicine, Institut de Neurociències, Universitat de Barcelona; CIBERSAM; August Pi I Sunyer Biomedical Research Institute (IDIBAPS)Department of Psychiatry, School of Medicine, University Hospital of Alava-Santiago, CIBERSAM, University of the Basque CountryDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad ComplutenseBarcelona Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAMDepartment of Child and Adolescent Psychiatry and Psychology, Institut Clinic de Neurociències, 2017SGR881, Hospital Clínic Universitari, CIBERSAMDepartment of Medicine and Psychiatry, Universidad de Zaragoza, Instituto de Investigación Sanitaria Aragón (IIS Aragón), CIBERSAMInstitute of Psychiatry and Mental Health, Hospital Clínico San Carlos, IdISSC, CIBERSAM, School of medicine, Universidad ComplutenseBarcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute; Department of Medicine, Institut de Neurociències, Universitat de Barcelona; CIBERSAM; August Pi I Sunyer Biomedical Research Institute (IDIBAPS)Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad ComplutenseDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad ComplutenseAbstract First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether the cortical changes that follow a FEP are progressive and whether age at onset modulates these changes remains unclear. This is a multicenter MRI study in a deeply phenotyped sample of 74 FEP patients with a wide age range at onset (15–35 years) and 64 neurotypical healthy controls (HC). All participants underwent two MRI scans with a 2-year follow-up interval. We computed the longitudinal percentage of change (PC) for cortical thickness (CT), surface area (CSA) and volume (CV) for frontal, temporal, parietal and occipital lobes. We used general linear models to assess group differences in PC as a function of age at FEP. We conducted post-hoc analyses for metrics where PC differed as a function of age at onset. We found a significant age-by-diagnosis interaction effect for PC of temporal lobe CT (d = 0.54; p = 002). In a post-hoc-analysis, adolescent-onset (≤19 y) FEP showed more severe longitudinal cortical thinning in the temporal lobe than adolescent HC. We did not find this difference in adult-onset FEP compared to adult HC. Our study suggests that, in individuals with psychosis, CT changes that follow the FEP are dependent on the age at first episode, with those with an earlier onset showing more pronounced cortical thinning in the temporal lobe.https://doi.org/10.1038/s41537-021-00196-7 |
| spellingShingle | Laura Pina-Camacho Kenia Martinez Covadonga M. Diaz-Caneja Gisela Mezquida Manuel J. Cuesta Carmen Moreno Silvia Amoretti Ana González-Pinto Celso Arango Eduard Vieta Josefina Castro-Fornieles Antonio Lobo David Fraguas Miguel Bernardo Joost Janssen Mara Parellada PEPs Group Cortical thinning over two years after first-episode psychosis depends on age of onset npj Schizophrenia |
| title | Cortical thinning over two years after first-episode psychosis depends on age of onset |
| title_full | Cortical thinning over two years after first-episode psychosis depends on age of onset |
| title_fullStr | Cortical thinning over two years after first-episode psychosis depends on age of onset |
| title_full_unstemmed | Cortical thinning over two years after first-episode psychosis depends on age of onset |
| title_short | Cortical thinning over two years after first-episode psychosis depends on age of onset |
| title_sort | cortical thinning over two years after first episode psychosis depends on age of onset |
| url | https://doi.org/10.1038/s41537-021-00196-7 |
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