Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition

Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition

Pulmonary arterial hypertension (PAH) caused by enhanced arterial pressure increases vessel resistance in the lung. Endothelial-to-mesenchymal transition (EndMT) plays key roles in the vascular remodeling in PAH. Naringin, a protective gaseous mediator is commonly extracted from tomatoes and citrus...

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Bibliographic Details
Main Authors: Yonghui Wu, Changhong Cai, Yijia Xiang, Huan Zhao, Lingchun Lv, Chunlai Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
naringin
pulmonary arterial hypertension
endothelial-to-mesenchymal transition
monocrotaline
endothelial cell
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.696135/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.696135/full

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