NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis

NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis

(1) Background: Monocytes and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome orchestrate lipid-driven amplification of vascular inflammation promoting the disruption of the fibrous cap. The components of the NLRP3 inflammasome are expressed in macrophages and...

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Bibliographic Details
Main Authors: Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, François Mach, Karim J. Brandt, Kapka Miteva
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
NLRP3 inflammasome activation
vascular smooth muscle
vascular smooth muscle phenotypic switch
atherosclerosis
atherosclerosis plaques stability
Online Access:https://www.mdpi.com/1422-0067/23/1/340

Internet

https://www.mdpi.com/1422-0067/23/1/340

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