Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

Abstract Background The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos with variable efficiency. Transcytosis...

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Bibliographic Details
Main Authors: Thomas J. Esparza, Shiran Su, Caroline M. Francescutti, Elvira Rodionova, Joong Hee Kim, David L. Brody
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood brain barrier
Transferrin receptor
Nanobody
Neurotensin
Histidine
P2X7 receptor
Online Access:https://doi.org/10.1186/s12987-023-00462-z

Internet

https://doi.org/10.1186/s12987-023-00462-z

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