DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway

DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway

Abstract Fanconi Anemia (FA) is a rare, inherited genomic instability disorder, caused by mutations in genes involved in the repair of interstrand DNA crosslinks (ICLs). The FA signaling network contains a unique nuclear protein complex that mediates the monoubiquitylation of the FANCD2 and FANCI he...

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Bibliographic Details
Main Authors: Sonali Bhattacharjee, Saikat Nandi
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Cell Communication and Signaling
Subjects:
DNA repair
Fanconi Anemia (FA) signaling network
DNA damage response
Cancer therapeutics
Synthetic lethality
Combination Therapy Genomic instability
Online Access:http://link.springer.com/article/10.1186/s12964-017-0195-9

Internet

http://link.springer.com/article/10.1186/s12964-017-0195-9

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