Therapeutic effect of palmitoylethanolamide in cognitive decline: A systematic review and preliminary meta-analysis of preclinical and clinical evidence

Cognitive decline is believed to be associated with neurodegenerative processes involving excitotoxicity, oxidative damage, inflammation, and microvascular and blood-brain barrier dysfunction. Interestingly, research evidence suggests upregulated synthesis of lipid signaling molecules as an endogeno...

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Bibliographic Details
Main Authors: Marco Colizzi, Riccardo Bortoletto, Chiara Colli, Enrico Bonomo, Daniele Pagliaro, Elisa Maso, Gianfranco Di Gennaro, Matteo Balestrieri
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1038122/full