Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance

Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance

Abstract Background Some membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member of RTKs, mediates cancer stem-like cells self-renewal to promote can...

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Bibliographic Details
Main Authors: Yingqiu Xie, Ayan A. Nurkesh, Nazgul Ibragimova, Zhuldyz Zhanzak, Aizhan Meyerbekova, Zhanna Alexeyeva, Aiya Yesbolatova, Madina Satayeva, Aidana Mustafa, Limara Manarbek, Aisulu Maipas, Akerke Altaikyzy, Zhibek Keneskhanova, Burkitkan Akbay, Zhenbang Chen
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Nuclear localized membrane protein (NLMP)
MET
Cell death
Drug resistance
Cancer evolution
Online Access:http://link.springer.com/article/10.1186/s13046-018-1004-z

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http://link.springer.com/article/10.1186/s13046-018-1004-z

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