The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol

The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol

IntroductionThe inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype,...

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Main Authors: José Lentilhas-Graça, Diogo J. Santos, João Afonso, Andreia Monteiro, Andreia G. Pinho, Vera M. Mendes, Marta S. Dias, Eduardo D. Gomes, Rui Lima, Luís S. Fernandes, Fernando Fernandes-Amorim, Inês M. Pereira, Nídia de Sousa, Jorge R. Cibrão, Aline M. Fernandes, Sofia C. Serra, Luís A. Rocha, Jonas Campos, Tiffany S. Pinho, Susana Monteiro, Bruno Manadas, António J. Salgado, Ramiro D. Almeida, Nuno A. Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
spinal cord injury
macrophages
secretome
neuroimmunology
neuroregeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354479/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1354479/full

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