Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although such inhibitors were effective, safety problems led to slow pharmacological development....

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Bibliographic Details
Main Authors: Mar Orzáez, Mónica Sancho, Sandra Marchán, Laura Mondragón, Rebeca Montava, Juan García Valero, Olatz Landeta, Gorka Basañez, Rodrigo J Carbajo, Antonio Pineda-Lucena, Jordi Bujons, Alejandra Moure, Angel Messeguer, Carmen Lagunas, Carmen Herrero, Enrique Pérez-Payá
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4203855?pdf=render

Internet

http://europepmc.org/articles/PMC4203855?pdf=render

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