CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors
Mismatch repair-deficient (dMMR) tumors show a good response toward immune checkpoint inhibitors (ICI), but developing resistance impairs patients’ outcomes. Here, we compared the therapeutic potential of an α-PD-L1 antibody with the CDK4/6 inhibitor abemaciclib in two preclinical mouse models of dM...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | OncoImmunology |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2094583 |