CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors

CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors

Mismatch repair-deficient (dMMR) tumors show a good response toward immune checkpoint inhibitors (ICI), but developing resistance impairs patients’ outcomes. Here, we compared the therapeutic potential of an α-PD-L1 antibody with the CDK4/6 inhibitor abemaciclib in two preclinical mouse models of dM...

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Bibliographic Details
Main Authors:	Inken Salewski, Julia Henne, Leonie Engster, Paula Krone, Bjoern Schneider, Caterina Redwanz, Heiko Lemcke, Larissa Henze, Christian Junghanss, Claudia Maletzki
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Series:	OncoImmunology
Online Access:	https://www.tandfonline.com/doi/10.1080/2162402X.2022.2094583

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