Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In Vivo

Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In Vivo

Powassan virus (POWV) is a tick-borne flavivirus (TBFV) that can cause severe encephalitis in humans with a case–fatality rate as high as 11%. Patients who survive severe encephalitic disease can develop long-term neurological sequelae that can be debilitating and life-long. In this study, we have s...

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Bibliographic Details
Main Authors: Jacob Nelson, Lorenzo Ochoa, Paula Villareal, Tiffany Dunn, Ping Wu, Gracie Vargas, Alexander N. Freiberg
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pathogens
Subjects:
powassan virus
west nile virus
human neural stem cell (hNSC)-derived neuron astrocyte co-culture
neuroinflammation
neurovirulence
laminal membrane structures
Online Access:https://www.mdpi.com/2076-0817/11/10/1218

Internet

https://www.mdpi.com/2076-0817/11/10/1218

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