Predicting Anticancer Drug Resistance Mediated by Mutations

Predicting Anticancer Drug Resistance Mediated by Mutations

Cancer drug resistance presents a challenge for precision medicine. Drug-resistant mutations are always emerging. In this study, we explored the relationship between drug-resistant mutations and drug resistance from the perspective of protein structure. By combining data from previously identified d...

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Bibliographic Details
Main Authors: Yu-Feng Lin, Jia-Jun Liu, Yu-Jen Chang, Chin-Sheng Yu, Wei Yi, Hsien-Yuan Lane, Chih-Hao Lu
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceuticals
Subjects:
cancer drug
drug resistance
single amino acid variation
protein structure
machine learning
feature selection
Online Access:https://www.mdpi.com/1424-8247/15/2/136

Internet

https://www.mdpi.com/1424-8247/15/2/136

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