Environmentally sensitive hotspots in the methylome of the early human embryo

Environmentally sensitive hotspots in the methylome of the early human embryo

In humans, DNA methylation marks inherited from gametes are largely erased following fertilisation, prior to construction of the embryonic methylome. Exploiting a natural experiment of seasonal variation including changes in diet and nutritional status in rural Gambia, we analysed three datasets cov...

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Bibliographic Details
Main Authors: Matt J Silver, Ayden Saffari, Noah J Kessler, Gririraj R Chandak, Caroline HD Fall, Prachand Issarapu, Akshay Dedaniya, Modupeh Betts, Sophie E Moore, Michael N Routledge, Zdenko Herceg, Cyrille Cuenin, Maria Derakhshan, Philip T James, David Monk, Andrew M Prentice
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
DNA methylation
early embryo
conception
metastable epiallele
nutrition
parent-of-origin effects
Online Access:https://elifesciences.org/articles/72031

Internet

https://elifesciences.org/articles/72031

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