Targeting catalase but not peroxiredoxins enhances arsenic trioxide-induced apoptosis in K562 cells.

Targeting catalase but not peroxiredoxins enhances arsenic trioxide-induced apoptosis in K562 cells.

Despite considerable efficacy of arsenic trioxide (As2O3) in acute promyelocytic leukemia (APL) treatment, other non-APL leukemias, such as chronic myeloid leukemia (CML), are less sensitive to As2O3 treatment. However, the underlying mechanism is not well understood. Here we show that relative As2O...

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Bibliographic Details
Main Authors: Li-Li Song, Yao-Yao Tu, Li Xia, Wei-Wei Wang, Wei Wei, Chun-Min Ma, Dong-Hua Wen, Hu Lei, Han-Zhang Xu, Ying-Li Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4130628?pdf=render

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http://europepmc.org/articles/PMC4130628?pdf=render

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