Activation of NOTCH1 by Shear Force Elicits Immediate Cytokine Expression in Human Chondrocytes

Osteoarthritis is caused by overloading of joints and is characterized by inflammation-induced disruption of cartilage structure. Current treatment strategy aims to relieve inflammation and prevent further deterioration of joint function. However, how mechanical force leads to inflammation and deter...

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Bibliographic Details
Main Authors: Hao-Jen Cheng, Wan-Ting Hsu, Cheng-Nan Chen, Chin Li
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/14/4958