Methylglyoxal evokes pain by stimulating TRPA1.

Methylglyoxal evokes pain by stimulating TRPA1.

Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound methylglyoxal (MG). Here we show that MG stimulates hete...

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Bibliographic Details
Main Authors: David A Andersson, Clive Gentry, Emily Light, Nisha Vastani, Julie Vallortigara, Angelika Bierhaus, Thomas Fleming, Stuart Bevan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805573?pdf=render

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http://europepmc.org/articles/PMC3805573?pdf=render

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