Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Highlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower nicotine withdrawal in female but not male smokers...

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Bibliographic Details
Main Authors: Andrew M. Novick, Korrina A. Duffy, Rachel L. Johnson, Mary D. Sammel, Wen Cao, Andrew A. Strasser, Mehmet Sofuoglu, Alexandra Kuzma, James Loughead, A. Leslie Morrow, C. Neill Epperson
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Biology of Sex Differences
Subjects:
Smoking
Progesterone
Allopregnanolone
Sex-differences
Neurosteroids
Online Access:https://doi.org/10.1186/s13293-022-00472-w

Internet

https://doi.org/10.1186/s13293-022-00472-w

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