Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone
Highlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower nicotine withdrawal in female but not male smokers...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-022-00472-w |
| _version_ | 1811257125120245760 |
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| author | Andrew M. Novick Korrina A. Duffy Rachel L. Johnson Mary D. Sammel Wen Cao Andrew A. Strasser Mehmet Sofuoglu Alexandra Kuzma James Loughead A. Leslie Morrow C. Neill Epperson |
| author_facet | Andrew M. Novick Korrina A. Duffy Rachel L. Johnson Mary D. Sammel Wen Cao Andrew A. Strasser Mehmet Sofuoglu Alexandra Kuzma James Loughead A. Leslie Morrow C. Neill Epperson |
| author_sort | Andrew M. Novick |
| collection | DOAJ |
| description | Highlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower nicotine withdrawal in female but not male smokers during a brief abstinence. Higher conversion of progesterone to allopregnanolone was associated with lower ratings of confusion and marginally lower ratings of fatigue in female but not male smokers. Irrespective of sex, higher conversion of progesterone to allopregnanolone was associated with stronger “good effects” and weaker “bad effects” of nicotine during active smoking. |
| first_indexed | 2024-04-12T17:51:37Z |
| format | Article |
| id | doaj.art-3e1906bc16fd4529a5d2f3a5e8ab85ce |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-12T17:51:37Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-3e1906bc16fd4529a5d2f3a5e8ab85ce2022-12-22T03:22:29ZengBMCBiology of Sex Differences2042-64102022-10-0113111410.1186/s13293-022-00472-wEffect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanoloneAndrew M. Novick0Korrina A. Duffy1Rachel L. Johnson2Mary D. Sammel3Wen Cao4Andrew A. Strasser5Mehmet Sofuoglu6Alexandra Kuzma7James Loughead8A. Leslie Morrow9C. Neill Epperson10Department of Psychiatry, School of Medicine, University of CO-Anschutz Medical CampusDepartment of Psychiatry, School of Medicine, University of CO-Anschutz Medical CampusDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of CO-Anschutz Medical CampusDepartment of Psychiatry, School of Medicine, University of CO-Anschutz Medical CampusDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Yale School of Medicine, Yale UniversityLarner College of Medicine, University of VermontDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartments of Psychiatry and Pharmacology and the Bowles Center for Alcohol Studies, University of North Carolina School of MedicineDepartment of Psychiatry, School of Medicine, University of CO-Anschutz Medical CampusHighlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower nicotine withdrawal in female but not male smokers during a brief abstinence. Higher conversion of progesterone to allopregnanolone was associated with lower ratings of confusion and marginally lower ratings of fatigue in female but not male smokers. Irrespective of sex, higher conversion of progesterone to allopregnanolone was associated with stronger “good effects” and weaker “bad effects” of nicotine during active smoking.https://doi.org/10.1186/s13293-022-00472-wSmokingProgesteroneAllopregnanoloneSex-differencesNeurosteroids |
| spellingShingle | Andrew M. Novick Korrina A. Duffy Rachel L. Johnson Mary D. Sammel Wen Cao Andrew A. Strasser Mehmet Sofuoglu Alexandra Kuzma James Loughead A. Leslie Morrow C. Neill Epperson Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone Biology of Sex Differences Smoking Progesterone Allopregnanolone Sex-differences Neurosteroids |
| title | Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone |
| title_full | Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone |
| title_fullStr | Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone |
| title_full_unstemmed | Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone |
| title_short | Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone |
| title_sort | effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues role of progesterone conversion to allopregnanolone |
| topic | Smoking Progesterone Allopregnanolone Sex-differences Neurosteroids |
| url | https://doi.org/10.1186/s13293-022-00472-w |
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