Aberrant SOX10 and RET expressions in patients with Hirschsprung disease

Aberrant SOX10 and RET expressions in patients with Hirschsprung disease

Abstract Background HSCR is a complex genetic disorder characterized by the absence of ganglion cells in the intestine, leading to a functional obstruction. It is due to a disruption of complex signaling pathways within the gene regulatory network (GRN) during the development of the enteric nervous...

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Main Authors: Gunadi, Verrell Christopher Amadeus, Fadila Dyah Trie Utami, Fiqih Vidiantoro Halim, Nabilah Anisa Novebri, Rahaditya Alrasyidi Hanggoro, Avinindita Nura Lestari, Kristy Iskandar, Andi Dwihantoro, Eko Purnomo
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Pediatrics
Subjects:
Hirschsprung disease
SOX10
RET
Enteric nervous system development
Gene regulatory network
Aberrant expressions
Online Access:https://doi.org/10.1186/s12887-024-04682-6

Internet

https://doi.org/10.1186/s12887-024-04682-6

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