Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity

Rocaglates are potent broad-spectrum antiviral compounds with a promising safety profile. They inhibit viral protein synthesis for different RNA viruses by clamping the 5′-UTRs of mRNAs onto the surface of the RNA helicase eIF4A. Apart from the natural rocaglate silvestrol, synthetic rocaglates like...

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Bibliographic Details
Main Authors: Wiebke Obermann, Alexandra Friedrich, Ramakanth Madhugiri, Paul Klemm, Jan Philipp Mengel, Torsten Hain, Stephan Pleschka, Hans-Guido Wendel, Roland K. Hartmann, Susanne Schiffmann, John Ziebuhr, Christin Müller, Arnold Grünweller
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Viruses
Subjects:
rocaglates
coronavirus
eIF4A
silvestrol
CR-1-31-B
zotatifin
Online Access:https://www.mdpi.com/1999-4915/14/3/519

Internet

https://www.mdpi.com/1999-4915/14/3/519

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