The Impaired Neurodevelopment of Human Neural Rosettes in HSV-1-Infected Early Brain Organoids

The Impaired Neurodevelopment of Human Neural Rosettes in HSV-1-Infected Early Brain Organoids

Intrauterine infections during pregnancy by herpes simplex virus (HSV) can cause significant neurodevelopmental deficits in the unborn/newborn, but clinical studies of pathogenesis are challenging, and while animal models can model some aspects of disease, in vitro studies of human neural cells prov...

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Bibliographic Details
Main Authors: Leonardo D’Aiuto, Jill K. Caldwell, Callen T. Wallace, Tristan R. Grams, Maribeth A. Wesesky, Joel A. Wood, Simon C. Watkins, Paul R. Kinchington, David C. Bloom, Vishwajit L. Nimgaonkar
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
brain organoids
herpes simplex virus (HSV)
human induced pluripotent stem cells (hiPSCs)
neural rosettes
neonatal herpes encephalitis
acyclovir resistance
Online Access:https://www.mdpi.com/2073-4409/11/22/3539

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https://www.mdpi.com/2073-4409/11/22/3539

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