Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF.

Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF.

BACKGROUND: Angiogenesis is a key hallmark of tumourigenesis and its inhibition is a proven strategy for the development of novel anti-cancer therapeutics. An important aspect of early angiogenesis is the co-ordinated migration and invasion of endothelial cells through the hypoxic tumour tissue. Cat...

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Bibliographic Details
Main Authors: Claire Ward, Diana Kuehn, Roberta E Burden, Julie A Gormley, Thomas J Jaquin, Mihaela Gazdoiu, Donna Small, Roy Bicknell, James A Johnston, Christopher J Scott, Shane A Olwill
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2932732?pdf=render

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http://europepmc.org/articles/PMC2932732?pdf=render

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