NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

Natural killer (NK) cell-based immunotherapy is a promising therapy for cancer patients. Inhibitory killer immunoglobulin-like receptors (KIRs) and NKG2A are required for NK cell licensing, but can also inhibit NK cell effector function. Upon reconstitution in a stem cell transplantation setting or...

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Bibliographic Details
Main Authors: Niken M. Mahaweni, Femke A. I. Ehlers, Subhashis Sarkar, Johanna W. H. Janssen, Marcel G. J. Tilanus, Gerard M. J. Bos, Lotte Wieten
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
natural killer cell
NKG2A
killer immunoglobulin-like receptor
HLA-E
multiple myeloma
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01415/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01415/full

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