Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity

Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity

Abstract Background and aims Previously, we found that FK506 binding protein 51 (Fkbp51) knockout (KO) mice resist high fat diet-induced fatty liver and alcohol-induced liver injury. The aim of this research is to identify the mechanism of Fkbp51 in liver injury. Methods Carbon tetrachloride (CCl4)-...

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Bibliographic Details
Main Authors: Bin Qiu, Zhaohui Zhong, Longyu Dou, Yuxue Xu, Yi Zou, Korri Weldon, Jun Wang, Lingling Zhang, Ming Liu, Kent E. Williams, John Paul Spence, Richard L. Bell, Zhao Lai, Weidong Yong, Tiebing Liang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell & Bioscience
Subjects:
FK506binding protein 5/Fkbp51
RNA-seq
Mitochondrial quality control (MQC)
SAFit2
Liver disease treatment
Online Access:https://doi.org/10.1186/s13578-023-01184-3

Internet

https://doi.org/10.1186/s13578-023-01184-3

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