Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome

Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome

Abstract Although Down syndrome (DS), the most common developmental genetic cause of intellectual disability, displays proliferation and migration deficits in the prenatal frontal cortex (FC), a knowledge gap exists on the effects of trisomy 21 upon postnatal cortical development. Here, we examined...

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Bibliographic Details
Main Authors: Emma C. Utagawa, David G. Moreno, Kristian T. Schafernak, Nicoleta C. Arva, Michael H. Malek-Ahmadi, Elliott J. Mufson, Sylvia E. Perez
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Acta Neuropathologica Communications
Subjects:
Down syndrome
Frontal cortex
Postnatal development
Calcium binding proteins
Neuronal maturation
Online Access:https://doi.org/10.1186/s40478-022-01385-w

Internet

https://doi.org/10.1186/s40478-022-01385-w

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