Hepsin promotes breast tumor growth signaling via the TGFβ‐EGFR axis

Hepsin promotes breast tumor growth signaling via the TGFβ‐EGFR axis

Hepsin, a type II transmembrane serine protease, is commonly overexpressed in prostate and breast cancer. The hepsin protein is stabilized by the Ras‐MAPK pathway, and, downstream, this protease regulates the degradation of extracellular matrix components and activates growth factor pathways, such a...

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Bibliographic Details
Main Authors: Denis Belitškin, Pauliina Munne, Shishir M. Pant, Johanna M. Anttila, Ilida Suleymanova, Kati Belitškina, Daniel Kirchhofer, James Janetka, Taivo Käsper, Sami Jalil, Jeroen Pouwels, Topi A. Tervonen, Juha Klefström
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Molecular Oncology
Subjects:
breast cancer
EGFR
HPN
mouse cancer model
patient‐derived explant culture model
TGFβ
Online Access:https://doi.org/10.1002/1878-0261.13545

Internet

https://doi.org/10.1002/1878-0261.13545

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