Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate

Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate

Lysosomal phospholipase A2 (LPLA2) is the PG to LPG converting enzyme in the BMP biosynthetic pathway, and changes in LPLA2 levels in cells affect cholesterol levels and late endosome/lysosome morphology.

Bibliographic Details
Main Authors: Jacinda Chen, Amaury Cazenave-Gassiot, Yimeng Xu, Paola Piroli, Robert Hwang, Laura DeFreitas, Robin Barry Chan, Gilbert Di Paolo, Renu Nandakumar, Markus R. Wenk, Catherine Marquer
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04573-z

Internet

https://doi.org/10.1038/s42003-023-04573-z

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