SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.

SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.

The increased expression of SIRT1 has recently been identified in numerous human tumors and a possible correlation with c-Myc oncogene has been proposed. However, it remains unclear whether SIRT1 functions as an oncogene or tumor suppressor. We sought to elucidate the role of SIRT1 in liver cancer u...

Full description

Bibliographic Details
Main Authors: Kyu Yun Jang, Sang Jae Noh, Nadja Lehwald, Guo-Zhong Tao, David I Bellovin, Ho Sung Park, Woo Sung Moon, Dean W Felsher, Karl G Sylvester
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3443243?pdf=render

Internet

http://europepmc.org/articles/PMC3443243?pdf=render

Similar Items