Synergistic Activity of Pep16, a Promising New Antibacterial Pseudopeptide against Multidrug-Resistant Organisms, in Combination with Colistin against Multidrug-Resistant <i>Escherichia coli</i>, In Vitro and in a Murine Peritonitis Model

Synergistic Activity of Pep16, a Promising New Antibacterial Pseudopeptide against Multidrug-Resistant Organisms, in Combination with Colistin against Multidrug-Resistant <i>Escherichia coli</i>, In Vitro and in a Murine Peritonitis Model

Colistin is a drug of last resort to treat extreme drug-resistant Enterobacterales, but is limited by dose-dependent toxicity and the emergence of resistance. A recently developed antimicrobial pseudopeptide, Pep16, which acts on the cell membrane, may be synergistic with colistin and limit the emer...

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Bibliographic Details
Main Authors: Samuel Chosidow, Bruno Fantin, Irène Nicolas, Jean-Baptiste Mascary, Françoise Chau, Valérie Bordeau, Marie-Clemence Verdier, Pierre Rocheteau, Francois Guérin, Vincent Cattoir, Victoire de Lastours
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antibiotics
Subjects:
<i>Escherichia coli</i>
multiresistance
antimicrobial peptides
colistin
murine models
Online Access:https://www.mdpi.com/2079-6382/12/1/81

Internet

https://www.mdpi.com/2079-6382/12/1/81

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