Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization

Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization

Abstract Background Low birth weight (LBW) is associated with intestinal inflammation and dysbiosis after birth. However, the underlying mechanism remains largely unknown. Objective In the present study, we aimed to investigate the metabolism, therapeutic potential, and mechanisms of action of bile...

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Bibliographic Details
Main Authors: Yu Pi, Yujun Wu, Xiangyu Zhang, Dongdong Lu, Dandan Han, Jiangchao Zhao, Xiaojiao Zheng, Shiyi Zhang, Hao Ye, Shuai Lian, Yu Bai, Zhenyu Wang, Shiyu Tao, Dongjiao Ni, Xinhua Zou, Wei Jia, Guolong Zhang, Defa Li, Junjun Wang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Microbiome
Subjects:
Low birth weight
Microbiome
Bile acids
Macrophage
Immunity
Online Access:https://doi.org/10.1186/s40168-022-01458-x

Internet

https://doi.org/10.1186/s40168-022-01458-x

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