Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice

Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice

Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response in lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. The present study shows that naturally occurring agei...

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Bibliographic Details
Main Authors: Kexiong Zhang, Lihui Wang, Xiaojing Hong, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Jun-Ping Liu
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
telomerase RNA component
telomere shortening
lung alveolar type 2 cells
senescence
apoptosis
differentiation
Online Access:https://www.mdpi.com/2073-4409/10/11/2892

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https://www.mdpi.com/2073-4409/10/11/2892

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