Selective miRNA inhibition in CD8+ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses

Selective miRNA inhibition in CD8+ cytotoxic T lymphocytes enhances HIV-1 specific cytotoxic responses

miRNAs dictate relevant virus-host interactions, offering new avenues for interventions to achieve an HIV remission. We aimed to enhance HIV-specific cytotoxic responses—a hallmark of natural HIV control— by miRNA modulation in T cells. We recruited 12 participants six elite controllers and six pati...

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Bibliographic Details
Main Authors: Nadia Madrid-Elena, Sergio Serrano-Villar, Carolina Gutiérrez, Beatriz Sastre, Matías Morín, Laura Luna, Laura Martín, Javier Santoyo-López, María Rosa López-Huertas, Elena Moreno, María Laura García-Bermejo, Miguel Ángel Moreno-Pelayo, Santiago Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
micro-RNA
cytotoxicity
cellular immunity
non-coding RNA
HIV
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.998368/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.998368/full

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