Lithocholic Acid Induces miR21, Promoting PTEN Inhibition via STAT3 and ERK-1/2 Signaling in Colorectal Cancer Cells

Lithocholic Acid Induces miR21, Promoting PTEN Inhibition via STAT3 and ERK-1/2 Signaling in Colorectal Cancer Cells

Micro-RNA-21 (miR-21) is a vital regulator of colorectal cancer (CRC) progression and has emerged as a potential therapeutic target in CRC treatment. Our study using real-time PCR assay found that a secondary bile acid, lithocholic acid (LCA), stimulated the expression of miR21 in the CRC cell lines...

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Bibliographic Details
Main Authors: Thinh-Thi Nguyen, Thuan-Trong Ung, Shinan Li, Dhiraj Kumar Sah, Sun-Young Park, Sen Lian, Young-Do Jung
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
miR21
lithocholic acid
colorectal cancer
STAT3
PTEN
Online Access:https://www.mdpi.com/1422-0067/22/19/10209

Internet

https://www.mdpi.com/1422-0067/22/19/10209

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