Human Post-Translational SUMOylation Modification of SARS-CoV-2 Nucleocapsid Protein Enhances Its Interaction Affinity with Itself and Plays a Critical Role in Its Nuclear Translocation

Human Post-Translational SUMOylation Modification of SARS-CoV-2 Nucleocapsid Protein Enhances Its Interaction Affinity with Itself and Plays a Critical Role in Its Nuclear Translocation

Viruses, such as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infect hosts and take advantage of host cellular machinery for genome replication and new virion production. Identifying and elucidating host pathways for viral infection is critical for understanding the development of t...

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Bibliographic Details
Main Authors: Vipul Madahar, Runrui Dang, Quanqing Zhang, Chuchu Liu, Victor G. J. Rodgers, Jiayu Liao
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Viruses
Subjects:
SARS-CoV-2 N protein
SUMOylation
qFRET
protein interaction dissociation constant K<sub>D</sub>
nuclear translocation
Online Access:https://www.mdpi.com/1999-4915/15/7/1600

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https://www.mdpi.com/1999-4915/15/7/1600

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