Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7.

Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7.

Elevated expression and activity of the epidermal growth factor receptor (EGFR)/protein kinase B (Akt) signaling pathway is associated with development, progression and treatment resistance of head and neck cancer (HNC). Several studies have demonstrated that microRNA-7 (miR-7) regulates EGFR expres...

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Bibliographic Details
Main Authors: Felicity C Kalinowski, Keith M Giles, Patrick A Candy, Alishum Ali, Clarissa Ganda, Michael R Epis, Rebecca J Webster, Peter J Leedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480380?pdf=render

Internet

http://europepmc.org/articles/PMC3480380?pdf=render

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