CD47 blockade enhances phagocytosis of cardiac cell debris by neutrophils

CD47 blockade enhances phagocytosis of cardiac cell debris by neutrophils

CD47 is a cell surface protein controlling phagocytotic activity of innate immune cells. CD47 blockade was investigated as an immune checkpoint therapy in cancer treatment, enhancing phagocytosis of tumor cells by macrophages. Anti-CD47 treatment also reduced injury size during reperfused acute myoc...

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Bibliographic Details
Main Authors: Elias Haj-Yehia, Sebastian Korste, Robert Jochem, Aldona Lusha, Anna Roth, Nina Dietzel, Josefine Niroomand, Pia Stock, Astrid M. Westendorf, Jan Buer, Ulrike B. Hendgen-Cotta, Tienush Rassaf, Matthias Totzeck
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:International Journal of Cardiology: Heart & Vasculature
Subjects:
CD47
Ischemia/reperfusion injury
Reperfused acute myocardial infarction
repAMI
Neutrophils
Phagocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906723001008

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http://www.sciencedirect.com/science/article/pii/S2352906723001008

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