A field-wide assessment of differential expression profiling by high-throughput sequencing reveals widespread bias.
We assess inferential quality in the field of differential expression profiling by high-throughput sequencing (HT-seq) based on analysis of datasets submitted from 2008 to 2020 to the NCBI GEO data repository. We take advantage of the parallel differential expression testing over thousands of genes,...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-03-01
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Series: | PLoS Biology |
Online Access: | https://doi.org/10.1371/journal.pbio.3002007 |