A local drug delivery system prolongs graft survival by dampening T cell infiltration and neutrophil extracellular trap formation in vascularized composite allografts

A local drug delivery system prolongs graft survival by dampening T cell infiltration and neutrophil extracellular trap formation in vascularized composite allografts

IntroductionThe standard treatment for preventing rejection in vascularized composite allotransplantation (VCA) currently relies on systemic immunosuppression, which exposes the host to well-known side effects. Locally administered immunosuppression strategies have shown promising results to bypass...

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Bibliographic Details
Main Authors: Isabel Arenas Hoyos, Anja Helmer, Anaïs Yerly, Ioana Lese, Stefanie Hirsiger, Lei Zhang, Daniela Casoni, Luisana Garcia, MariaFrancesca Petrucci, Sabine E. Hammer, Tereza Duckova, Yara Banz, Matteo Montani, Mihai Constantinescu, Esther Vögelin, Gregor Bordon, Simone Aleandri, Jean-Christophe Prost, Adriano Taddeo, Paola Luciani, Robert Rieben, Nicoletta Sorvillo, Radu Olariu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Immunology
Subjects:
vascularized composite allotransplantation (VCA)
transplantation immunology
tacrolimus
local immunosuppression
calcineurin inhibitors (CNIs)
drug delivery systems (DDSs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1387945/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1387945/full

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