Sirt1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription

Sirt1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription

Abstract Background The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad proteins, TGFβ signaling intracellular transducers, object of post-transla...

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Bibliographic Details
Main Authors: Eva María García-Vizcaíno, Sergio Liarte, José Luis Alonso-Romero, Francisco José Nicolás
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Cell Communication and Signaling
Subjects:
Sirt1
TGFβ-signaling
Tumor transformation
Protein interaction
Gene transcription regulation
Online Access:http://link.springer.com/article/10.1186/s12964-017-0205-y

Internet

http://link.springer.com/article/10.1186/s12964-017-0205-y

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